PAPER Topics

Start of Term Paper
Keratinization, absence of granular layer, and depositation of antibodies and complement components in the stratum corneum. Most notable is the hyperproliferation of keratinocytes in the epidermis. These keratinocytes exhibit an increased mitot ....

Middle of Term Paper
... equally. There are two types of the disease. Type I generally occurs during adolescence, with an average age of onset of sixteen years for females and twenty-two years for males. Type II affects people over sixty years of age. There are several immunological abnormalities associated with psoriasis. Early psoriatic changes occur in advancing lesions before the accumulation of inflammatory cells. These changes are mediated by activated CD4+ T lymphocytes and can be detected before visible pathology to the skin occurs. Activated T lymphocytes exhibiting an increase in HLA-DR and IL-2R can be seen in close proximity to Langerhans ...