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Permeability Of Hydrophilic
Start of Term Paper
SUMMARY
Investigations of the integrity and transport characteristics of 2/4/A1 cells
have been done in this report. The cell line was isolated from rat fetal
intestinal epithelial cells and transfected with thermolabile SV40 large T
antigen.
.... Middle of Term Paper
... confirmed formation
of tight and adherence junctions. Transepithelial resistance reached a plateau
of 25-35 Ohm.cm2, which was similar to the small intestine. In transport studies
2/4/A1 cell line monolayers selectively restricted the permeation of hydrophilic
permeability markers proportional to molecular weight and discriminated more
accurately between the molecules of intermediate molecular weight compared to
Caco-2 cells.
These results indicated that 2/4/A1 cells could be used as a model for
hydrophilic drug absorption.
INTRODUCTION
The small intestine plays a crucial role in the absorption of drugs and
nutrients. Exogenous su ... |
| Number of Words: 2422 |
Approximate Pages: 9 |
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